... For example, some anti-cheat engines for games which shall not be named may scan the entire local filesystem and even upload suspicious files to their own servers. I personally would never want to run such applications unsandboxed with my own computer. And since all operating system sandboxes on PC (non-mobile OSes) are not widely used / not enforced / hard to configure, the only way is really things like WASM, WebGL and all the web stuff people might not like.
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